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DEVELOPMENTAL TOXICOLOGY

A new target for thalidomide

One mechanism of thalidomide teratogenicity involves binding to the CUL4–CRBN E3 ubiquitin ligase complex, which then mediates the degradation of transcription factors. New studies reveal that species-specific variants of the transcription factor SALL4 are differentially ubiquitinated and degraded via the thalidomide-bound complex.

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Fig. 1: Variants of SALL4 determine the species-specific nature of susceptibility to thalidomide teratogenicity.

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Correspondence to Peter G. Wells.

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Wells, P.G. A new target for thalidomide. Nat Chem Biol 14, 904–905 (2018). https://doi.org/10.1038/s41589-018-0134-0

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