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T CELL RECOGNITION

Flipping out the peptide

T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.

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The author declares no competing interests.

Correspondence to Stephanie Gras.

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Fig. 1: The MMW10-peptide C terminus is flipped out by the DMF5 TCR.