T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.
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Gras, S. Flipping out the peptide. Nat Chem Biol 14, 905–906 (2018). https://doi.org/10.1038/s41589-018-0133-1
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DOI: https://doi.org/10.1038/s41589-018-0133-1