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An optical sensor to monitor dynamics of extracellular glycine

Nature Chemical Biology volume 14, pages 835–836 (2018)Cite this article

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A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation.

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Fig. 1: An optical sensor to monitor glycine levels in the brain.

References

  1. Zhang, W.H. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0108-2 (2018).

  2. Iacobucci, G. J. & Popescu, G. K. Nat. Rev. Neurosci. 18, 236–249 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Henneberger, C., Papouin, T., Oliet, S. H. & Rusakov, D. A. Nature 463, 232–236 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Papouin, T. et al. Cell 150, 633–646 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Si, B. & Song, E. Chemosensors (Basel) 6, 1–24 (2018).

    Article  Google Scholar 

  6. Richard Sun, X., Giovannucci, A., Sgro, A. E. & Wang, S. S. Cell 149, 1650–1650.e2 (2012).

    Article  CAS  PubMed  Google Scholar 

  7. Wang, H., Jing, M. & Li, Y. Curr. Opin. Neurobiol. 50, 171–178 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. UCL Queen Square Institute of Neurology, University College London, Queen Square, London, UK

    Dmitri A. Rusakov

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  1. Dmitri A. Rusakov
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Correspondence to Dmitri A. Rusakov.

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The author declares no competing interests.

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Rusakov, D.A. An optical sensor to monitor dynamics of extracellular glycine. Nat Chem Biol 14, 835–836 (2018). https://doi.org/10.1038/s41589-018-0123-3

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