A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation.
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References
Zhang, W.H. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0108-2 (2018).
Iacobucci, G. J. & Popescu, G. K. Nat. Rev. Neurosci. 18, 236–249 (2017).
Henneberger, C., Papouin, T., Oliet, S. H. & Rusakov, D. A. Nature 463, 232–236 (2010).
Papouin, T. et al. Cell 150, 633–646 (2012).
Si, B. & Song, E. Chemosensors (Basel) 6, 1–24 (2018).
Richard Sun, X., Giovannucci, A., Sgro, A. E. & Wang, S. S. Cell 149, 1650–1650.e2 (2012).
Wang, H., Jing, M. & Li, Y. Curr. Opin. Neurobiol. 50, 171–178 (2018).
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Rusakov, D.A. An optical sensor to monitor dynamics of extracellular glycine. Nat Chem Biol 14, 835–836 (2018). https://doi.org/10.1038/s41589-018-0123-3
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DOI: https://doi.org/10.1038/s41589-018-0123-3