Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Mimicking cross-α amyloids

The design of spiraling cross-α amyloid-like structures reveals fascinating supermolecular fibrils of diverse compactness and stability. The small sequence variations governing cross-α self-assembly properties concur with amyloids being basic building blocks of life and natural targets for microbial structural mimicry.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Polymorphic amyloid-like fibrils and structural mimicry.


  1. Eisenberg, D. S. & Sawaya, M. R. Annu. Rev. Biochem. 86, 69–95 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Salinas, N., Colletier, J. P., Moshe, A. & Landau, M. Nat. Commun. (in the press).

  3. Tayeb-Fligelman, E. et al. Science 355, 831–833 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Zhang, S.-Q. Nat. Chem. Biol. (2018).

  5. Hughes, M. P. et al. Science 359, 698–701 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Luo, F. et al. Nat. Struct. Mol. Biol. 25, 341–346 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Jacobs, M. D. & Harrison, S. C. Cell 95, 749–758 (1998).

    Article  CAS  PubMed  Google Scholar 

  8. Plückthun, A. Annu. Rev. Pharmacol. Toxicol. 55, 489–511 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Rout, S. K., Friedmann, M. P., Riek, R. & Greenwald, J. Nat. Commun. 9, 234 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Friedland, R. P. J. Alzheimers Dis. 45, 349–362 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Meytal Landau.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Landau, M. Mimicking cross-α amyloids. Nat Chem Biol 14, 833–834 (2018).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing