A remote control for switching

Article metrics

Calcium channels are crucial regulators of a broad range of biological processes. A photoswitchable chemical probe allows the opening and closing of these channels with unprecedented temporal resolution, providing new opportunities to study calcium-dependent signaling pathways in real time.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Optical control of calcium channels.


  1. 1.

    Fehrentz, F. et al. Nat. Chem. Biol. (2018).

  2. 2.

    Szymański, W., Beierle, J. M., Kistemaker, H. A., Velema, W. A. & Feringa, B. L. Chem. Rev. 113, 6114–6178 (2013).

  3. 3.

    Hartley, G. S. Nature 140, 281 (1937).

  4. 4.

    Volgraf, M. et al. Nat. Chem. Biol. 2, 47–52 (2006).

  5. 5.

    Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymanski, W. & Feringa, B. L. Angew. Chem. Int. Edn. Engl. 55, 10978–10999 (2016).

  6. 6.

    Morad, M., Goldman, Y. E. & Trentham, D. R. Nature 304, 635–638 (1983).

  7. 7.

    Kang, S. K. et al. Nature 530, 71–76 (2016).

  8. 8.

    Fernandez, A. et al. ACS Cent. Sci. 3, 995–1005 (2017).

  9. 9.

    Klaue, K., Garmshausen, Y. & Hecht, S. Angew. Chem. Int. Edn. Engl. 57, 1414–1417 (2018).

Download references

Author information

Correspondence to Marc Vendrell.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vendrell, M. A remote control for switching. Nat Chem Biol 14, 749–750 (2018) doi:10.1038/s41589-018-0107-3

Download citation