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Antigen processing movers and shakers

Monitoring MHC-I dynamics upon binding to its chaperone TAPBPR helps us understand how optimal peptide sequences are selected for presentation and coordinated with release of the chaperone from the ternary peptide–MHC-I–TAPBPR complex.

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Fig. 1: Peptides compete for binding to the TAPBPR-bound intermediate state of MHC I.


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Correspondence to Tim Elliott.

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Elliott, T. Antigen processing movers and shakers. Nat Chem Biol 14, 747–748 (2018).

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