Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BEHAVIORAL PHARMACOLOGY

Copper on the brain

Understanding how metals contribute to brain function is a major health priority. A new study combining pharmacology and genetics implicates the accumulation of copper in a brain arousal center as a regulator of zebrafish activity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: During wakefulness, the locus coeruleus (LC) delivers norepinephrine (NE) across the brain to maintain arousal.

References

  1. Bush, A. I. Curr. Opin. Chem. Biol. 4, 184–191 (2000).

    Article  CAS  PubMed  Google Scholar 

  2. Xiao, T. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0062-z (2018).

  3. Ackerman, C. M. & Chang, C. J. J. Biol. Chem. 293, 4628–4635 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. Warren, P. J., Earl, C. J. & Thompson, R. H. Brain 83, 709–717 (1960).

    Article  CAS  PubMed  Google Scholar 

  5. Singh, C., Oikonomou, G. & Prober, D. A. eLife 4, e07000 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Nevsimalova, S. et al. Eur. J. Neurol. 18, 184–190 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Madsen, E. C. & Gitlin, J. D. PLoS Genet. 4, e1000261 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Madsen, E. & Gitlin, J. D. Annu. Rev. Neurosci. 30, 317–337 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Orger, M. B. & de Polavieja, G. G. Annu. Rev. Neurosci. 40, 125–147 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Tuschl, K. et al. Nat. Commun. 7, 11601 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jason Rihel.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rihel, J. Copper on the brain. Nat Chem Biol 14, 638–639 (2018). https://doi.org/10.1038/s41589-018-0089-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-018-0089-1

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing