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Vitamin B12 import is all about timing

Nature Chemical Biology volume 14, pages 640–641 (2018)Cite this article

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Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

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Fig. 1: The transport cycle of BtuCD-F can be divided into a futile cycle in the absence of the SBP and a productive cycle in the presence of vitamin B12-loaded SBP.

Katie Vicari/Springer Nature

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  1. Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

    Lutz Schmitt

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  1. Lutz Schmitt
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Correspondence to Lutz Schmitt.

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Schmitt, L. Vitamin B12 import is all about timing. Nat Chem Biol 14, 640–641 (2018). https://doi.org/10.1038/s41589-018-0087-3

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