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Cancer Systems Biology

Unraveling the rewired network

Nature Chemical Biology (2018) | Download Citation

Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.

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Author information

Affiliations

  1. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    • Vinayak Palve
    • , Brent M. Kuenzi
    •  & Uwe Rix

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Uwe Rix.

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DOI

https://doi.org/10.1038/s41589-018-0083-7