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Cancer Systems Biology

Unraveling the rewired network

Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.

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  1. Duncan, J. S. et al. Cell 149, 307–321 (2012).

    CAS  Article  Google Scholar 

  2. Bai, Y. et al. Cancer Res. 74, 7217–7228 (2014).

    CAS  Article  Google Scholar 

  3. Donnella, H. J. et al. Nat. Chem. Biol. (2018).

  4. Cancer Genome Atlas Network. Nature 490, 61–70 (2012).

    Article  Google Scholar 

  5. Rodon, J., Dienstmann, R., Serra, V. & Tabernero, J. Nat. Rev. Clin. Oncol. 10, 143–153 (2013).

    CAS  Article  Google Scholar 

  6. Bantscheff, M. et al. Nat. Biotechnol. 25, 1035–1044 (2007).

    CAS  Article  Google Scholar 

  7. den Hollander, J. et al. Blood 116, 1498–1505 (2010).

    Article  Google Scholar 

  8. Brewer Savannah, K. J. et al. Clin. Cancer Res. 18, 4633–4645 (2012).

    CAS  Article  Google Scholar 

  9. Katsha, A. et al. Clin. Cancer Res. 23, 3756–3768 (2017).

    CAS  Article  Google Scholar 

  10. Zheng, X. et al. Oncogene 37, 502–511 (2018).

    CAS  Article  Google Scholar 

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Correspondence to Uwe Rix.

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Palve, V., Kuenzi, B.M. & Rix, U. Unraveling the rewired network. Nat Chem Biol 14, 746–747 (2018).

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