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Cancer Systems Biology

Unraveling the rewired network

Nature Chemical Biology volume 14, pages 746–747 (2018)Cite this article

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Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.

Breast cancer is one of the most common cancers worldwide, and mortality rates remain high despite the presence of well characterized, clinically relevant biomarkers and matching therapies. Mutations that activate the PI3K–AKT–mTOR pathway are frequently observed in breast cancer, particularly in hormone receptor (HR) and HER2-positive subtypes4. Despite the development of multiple agents that target this pathway, the clinical success has been limited5, suggesting that additional factors such as drug-induced signaling adaptations and kinome rewiring may modulate the cellular response to these treatments and drive resistance.

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Authors and Affiliations

  1. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Vinayak Palve, Brent M. Kuenzi & Uwe Rix

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  1. Vinayak Palve
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  2. Brent M. Kuenzi
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  3. Uwe Rix
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Correspondence to Uwe Rix.

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Palve, V., Kuenzi, B.M. & Rix, U. Unraveling the rewired network. Nat Chem Biol 14, 746–747 (2018). https://doi.org/10.1038/s41589-018-0083-7

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