Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.
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Palve, V., Kuenzi, B.M. & Rix, U. Unraveling the rewired network. Nat Chem Biol 14, 746–747 (2018). https://doi.org/10.1038/s41589-018-0083-7