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Enzymes emerge by upcycling

Catalytic activity is a critical protein function, but its natural evolution has never been observed. Researchers have now revealed the mutations and biochemical mechanisms by which two ancient nonenzymatic proteins acquired catalytic activity.

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Fig. 1: Enzyme activity evolved by activating existing residues and quenching dynamics.


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Correspondence to Michael J. Harms.

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Harms, M.J. Enzymes emerge by upcycling. Nat Chem Biol 14, 526–527 (2018).

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