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Enzymes emerge by upcycling

Nature Chemical Biologyvolume 14pages526527 (2018) | Download Citation

Catalytic activity is a critical protein function, but its natural evolution has never been observed. Researchers have now revealed the mutations and biochemical mechanisms by which two ancient nonenzymatic proteins acquired catalytic activity.

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  1. Institute of Molecular Biology and Chemistry and Biochemistry Department, University of Oregon, Eugene, OR, USA

    • Michael J. Harms


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The author declares no competing interests.

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Correspondence to Michael J. Harms.

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