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PROTEIN DEGRADATION

Understanding the Pro/N-end rule pathway

Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of substrates by this proteolytic system.

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Fig. 1: Structural basis of N-degron recognition.

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Correspondence to David A. Dougan or Alexander Varshavsky.

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Dougan, D.A., Varshavsky, A. Understanding the Pro/N-end rule pathway. Nat Chem Biol 14, 415–416 (2018). https://doi.org/10.1038/s41589-018-0045-0

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