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PROTEIN DEGRADATION

Understanding the Pro/N-end rule pathway

Nature Chemical Biology volume 14, pages 415–416 (2018)Cite this article

Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of substrates by this proteolytic system.

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Fig. 1: Structural basis of N-degron recognition.

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Authors and Affiliations

  1. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

    David A. Dougan

  2. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA

    Alexander Varshavsky

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  1. David A. Dougan
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  2. Alexander Varshavsky
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Correspondence to David A. Dougan or Alexander Varshavsky.

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The authors declare no competing interests.

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Dougan, D.A., Varshavsky, A. Understanding the Pro/N-end rule pathway. Nat Chem Biol 14, 415–416 (2018). https://doi.org/10.1038/s41589-018-0045-0

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