Proteins brought to an E3 ubiquitin ligase are polyubiquitylated for rapid degradation via the proteasome. A new study developed a tag-based degradation system using heterobifunctional degradation inducers called dTAGs, which rapidly depleted FKBP12F36V-fused proteins in cultured cells and in mice.
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References
Nabet, B. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0021-8 (2018).
Sakamoto, K. M. et al. Proc. Natl. Acad. Sci. USA 98, 8554–8559 (2001).
Toure, M. & Crews, C. M. Angew. Chem. Int. Edn. Engl. 55, 1966–1973 (2016).
Winter, G. E. et al. Science 348, 1376–1381 (2015).
Ito, T. et al. Science 327, 1345–1350 (2010).
Natsume, T. & Kanemaki, M. T. Annu. Rev. Genet. 51, 83–102 (2017).
Clackson, T. et al. Proc. Natl. Acad. Sci. USA 95, 10437–10442 (1998).
Shi, J. & Vakoc, C. R. Mol. Cell 54, 728–736 (2014).
Weintraub, A. S. et al. Cell 171, 1573–1588 (2017).
Erb, M. A. et al. Nature 543, 270–274 (2017).
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Yesbolatova, A., Kanemaki, M.T. TAGing for destruction. Nat Chem Biol 14, 414–415 (2018). https://doi.org/10.1038/s41589-018-0024-5
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DOI: https://doi.org/10.1038/s41589-018-0024-5
