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PROTEIN DEGRADATION

TAGing for destruction

Proteins brought to an E3 ubiquitin ligase are polyubiquitylated for rapid degradation via the proteasome. A new study developed a tag-based degradation system using heterobifunctional degradation inducers called dTAGs, which rapidly depleted FKBP12F36V-fused proteins in cultured cells and in mice.

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Fig. 1: The principle of the PROTAC, dFKBP12-1 and dTAG systems.

References

  1. Nabet, B. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0021-8 (2018).

  2. Sakamoto, K. M. et al. Proc. Natl. Acad. Sci. USA 98, 8554–8559 (2001).

    CAS  Article  Google Scholar 

  3. Toure, M. & Crews, C. M. Angew. Chem. Int. Edn. Engl. 55, 1966–1973 (2016).

    CAS  Article  Google Scholar 

  4. Winter, G. E. et al. Science 348, 1376–1381 (2015).

    CAS  Article  Google Scholar 

  5. Ito, T. et al. Science 327, 1345–1350 (2010).

    CAS  Article  Google Scholar 

  6. Natsume, T. & Kanemaki, M. T. Annu. Rev. Genet. 51, 83–102 (2017).

    CAS  Article  Google Scholar 

  7. Clackson, T. et al. Proc. Natl. Acad. Sci. USA 95, 10437–10442 (1998).

    CAS  Article  Google Scholar 

  8. Shi, J. & Vakoc, C. R. Mol. Cell 54, 728–736 (2014).

    CAS  Article  Google Scholar 

  9. Weintraub, A. S. et al. Cell 171, 1573–1588 (2017).

    CAS  Article  Google Scholar 

  10. Erb, M. A. et al. Nature 543, 270–274 (2017).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Masato T. Kanemaki.

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Yesbolatova, A., Kanemaki, M.T. TAGing for destruction. Nat Chem Biol 14, 414–415 (2018). https://doi.org/10.1038/s41589-018-0024-5

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  • DOI: https://doi.org/10.1038/s41589-018-0024-5

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