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TAGing for destruction

Proteins brought to an E3 ubiquitin ligase are polyubiquitylated for rapid degradation via the proteasome. A new study developed a tag-based degradation system using heterobifunctional degradation inducers called dTAGs, which rapidly depleted FKBP12F36V-fused proteins in cultured cells and in mice.

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Fig. 1: The principle of the PROTAC, dFKBP12-1 and dTAG systems.


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Correspondence to Masato T. Kanemaki.

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Yesbolatova, A., Kanemaki, M.T. TAGing for destruction. Nat Chem Biol 14, 414–415 (2018).

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