Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CHAPERONES

Folding against the wind

Many thermodynamically unfavorable processes in biology are powered by ATP, the energy currency of the cell. New evidence suggests that chaperone-mediated protein stabilization may need to be added to that list.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Proteins tend to unfold when facing adverse conditions.

Billy Chrisnada from B’signs

References

  1. Goloubinoff, P., Sassi, A. S., Fauvet, B., Barducci, A. & de los Rios, P. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0013-8 (2018).

  2. Hartl, F. U., Bracher, A. & Hayer-Hartl, M. Nature 475, 324–332 (2011).

    Article  CAS  Google Scholar 

  3. Horwich, A. L., Apetri, A. C. & Fenton, W. A. FEBS Lett. 583, 2654–2662 (2009).

    Article  CAS  Google Scholar 

  4. Bardwell, J. C. A. & Jakob, U. Trends Biochem. Sci. 37, 517–525 (2012).

    Article  CAS  Google Scholar 

  5. Gray, M. J. et al. Mol. Cell 53, 689–699 (2014).

    Article  CAS  Google Scholar 

  6. Ornes, S. Proc. Natl. Acad. Sci. USA 114, 423–424 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James C. A. Bardwell.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Stull, F., Bardwell, J.C.A. Folding against the wind. Nat Chem Biol 14, 329–330 (2018). https://doi.org/10.1038/s41589-018-0016-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-018-0016-5

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing