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X-chromosome inactivation

Structural remodeling of the inactive X chromosome during early mouse development

Nature Genetics (2024)Cite this article

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The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.

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Fig. 1: X chromosome architecture dynamics during early mouse development.

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Authors and Affiliations

  1. Systems Epigenetics, Otto Warburg Laboratories, Max Planck Institute for Molecular Genetics, Berlin, Germany

    Edda G. Schulz & Alexandra Martitz

  2. Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany

    Alexandra Martitz

Authors
  1. Edda G. Schulz
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  2. Alexandra Martitz
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Correspondence to Edda G. Schulz.

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The authors declare no competing interests.

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Schulz, E.G., Martitz, A. Structural remodeling of the inactive X chromosome during early mouse development. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01936-y

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