Genetic constraint identifies genes under selection against loss-of-function, but existing methods are inaccurate for shorter genes. A new study overcomes this key limitation to ascribe more confident predictions to all human protein-coding genes.
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Acknowledgements
N.W. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (220134/Z/20/Z).
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N.W. receives research funding from Novo Nordisk and has consulted for ArgoBio studio.
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Whiffin, N. Improving estimates of loss-of-function constraint for short genes. Nat Genet 56, 1544–1545 (2024). https://doi.org/10.1038/s41588-024-01829-0
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DOI: https://doi.org/10.1038/s41588-024-01829-0
