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High-throughput fitness screens link genes to unique phenotypes in human-restricted Salmonella

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We used high-throughput transposon screens to examine the responses of generalist and host-adapted Salmonella enterica serovars to 25 stress conditions that recapitulate key stages of human infection. We identified and characterized numerous typhoid-specific gene networks, revealing a role for specific pseudogenes in shaping bacterial fitness outcomes.

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Fig. 1: Using Rb-Tn-seq to capture functional diversity of Salmonella.

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  • 20 June 2024

    In the version of the article initially published, “Created with Biorender.com” was missing from the Fig. 1 legend and has now been added.

References

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This is a summary of: Wang, B. X. et al. High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection. Nat. Genet. https://doi.org/10.1038/s41588-024-01779-7 (2024).

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High-throughput fitness screens link genes to unique phenotypes in human-restricted Salmonella. Nat Genet 56, 1053–1054 (2024). https://doi.org/10.1038/s41588-024-01780-0

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