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Novel somatic mutations in blood driving age-related clonal hematopoiesis

An analysis of somatic mutations in blood exomes from 200,618 individuals revealed previously unrecognized genes driving clonal hematopoiesis. Mutations in these genes showed age-dependent clonal expansion and their presence correlated with heightened risks of infection, death and hematological malignancy.

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Fig. 1: Identifying positive selection in whole blood exomes.

References

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This is a summary of: Bernstein, N. et al. Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis. Nat. Genet. https://doi.org/10.1038/s41588-024-01755-1 (2024).

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Novel somatic mutations in blood driving age-related clonal hematopoiesis. Nat Genet 56, 1049–1050 (2024). https://doi.org/10.1038/s41588-024-01756-0

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