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Chromatin modifications integrate cis genomic context to instruct transcriptional outputs

By developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise effect of chromatin modifications is influenced by multiple contextual factors, including the underlying DNA sequence, transcription factor occupancy and genomic positioning.

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Fig. 1: A flexible system for testing the causal role of epigenetic marks in transcription regulation.

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This is a summary of: Policarpi, C. et al. Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications. Nat. Genet. https://doi.org/10.1038/s41588-024-01706-w (2024).

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Chromatin modifications integrate cis genomic context to instruct transcriptional outputs. Nat Genet 56, 1051–1052 (2024). https://doi.org/10.1038/s41588-024-01705-x

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