Polymorphisms in the non-coding genome affect genetic circuits and result in variable immune responses across individuals. Here we report a genetic circuit involving a long non-coding RNA (lncRNA) that spatially coordinates chromatin contacts to control pro- and anti-inflammatory gene expression and shape immune responses of healthy individuals to pathogens or vaccination.
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This is a summary of: Fok, E. T. et al. A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation. Nat. Genet. https://doi.org/10.1038/s41588-023-01598-2 (2023).
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A lncRNA–chromatin circuit regulates IL-1β-driven inflammation. Nat Genet 56, 21–22 (2024). https://doi.org/10.1038/s41588-023-01605-6
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DOI: https://doi.org/10.1038/s41588-023-01605-6
