We present an analysis that shows that although nearly half of the human genome comprises repetitive sequences, recombination between homologous repeats has a minor role in cancer chromosomal evolution.
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This is a summary of: Choo, Z.-N. et al. Most large structural variants in cancer genomes can be detected without long reads. Nat. Genet. https://doi.org/10.1038/s41588-023-01540-6 (2023).
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A mass balance principle for finding loose ends in cancer genomes. Nat Genet 55, 2031–2032 (2023). https://doi.org/10.1038/s41588-023-01539-z