Transformation of a myeloproliferative neoplasm to a secondary acute myeloid leukemia is rare but devastating. Single-cell, multi-omic characterization of hematopoietic stem and progenitor cells now shows the role of inflammation in transformation driven by mutations in TP53, with effects on the mutant clone but also non-mutant counterparts.
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The authors declare no competing interests.
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Benabid, A., Schneider, R.K. Inflammation drives pressure on TP53 mutant clones in myeloproliferative neoplasms. Nat Genet 55, 1432–1434 (2023). https://doi.org/10.1038/s41588-023-01479-8