We introduce scEC&T-seq, a new single-cell sequencing method that enables parallel profiling of extrachromosomal circular DNA and mRNAs in single cells. Using scEC&T-seq, we characterized all types of circular DNA elements in single human cancer cells and profiled the intercellular heterogeneity and structural dynamics of cancer-specific extrachromosomal DNA.
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References
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This is a summary of: González, R. C. et al. Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nat. Genet. https://doi.org/10.1038/s41588-023-01386-y (2023).
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Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq. Nat Genet 55, 740–741 (2023). https://doi.org/10.1038/s41588-023-01385-z
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DOI: https://doi.org/10.1038/s41588-023-01385-z
