A new study deciphers the origin and evolution of childhood neuroblastoma using genome sequencing data, mathematical models and statistical inference, showing how neuroblastoma evolution is an accurate predictor of outcome.
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References
Nowell, P. C. Science 194, 23–28 (1976).
Körber, V. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01332-y (2023).
Brodeur, G. M. Nat. Rev. Cancer 3, 203–216 (2003).
Turajlic, S., Sottoriva, A., Graham, T. & Swanton, C. Nat. Rev. Genet. 20, 404–416 (2019).
Sansregret, L. & Swanton, C. Cold Spring Harb. Perspect. Med. 7, a028373 (2017).
Alexandrov, L. B. et al. Nature 500, 415–421 (2013).
Spiteri, I. et al. Ann. Oncol. 30, 456–463 (2019).
Caravagna, G. et al. Nat. Methods 15, 707–714 (2018).
Gao, J. & Pickett, H. A. Nat. Rev. Cancer 22, 515–532 (2022).
Beaumont, M. A., Zhang, W. & Balding, D. J. Genetics 162, 2025–2035 (2002).
Otto, S. P. & Day, T. A Biologist’s Guide to Mathematical Modeling in Ecology and Evolution (Princeton Univ. Press, 2011).
Bishop, C. M. Pattern Recognition and Machine Learning (Springer Nature, 2006).
Topol, E. J. Nat. Med. 25, 44–56 (2019).
Beerenwinkel, N., Schwarz, R. F., Gerstung, M. & Markowetz, F. Syst. Biol. 64, e1–e25 (2015).
Caravagna, G. et al. Nat. Genet. 52, 898–907 (2020).
Acknowledgements
The author acknowledges funding from the Italian Foundation for Cancer Research (AIRC) under MFAG 2020, ID 24913 project, PI Giulio Caravagna.
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Caravagna, G. Mathematical modeling of neuroblastoma associates evolutionary patterns with outcomes. Nat Genet 55, 530–531 (2023). https://doi.org/10.1038/s41588-023-01358-2
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DOI: https://doi.org/10.1038/s41588-023-01358-2
