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Prevalent putative chromatin bivalency and partial resetting of H3K27me3 in plant sperm

How histone modifications are reprogrammed through germline development in plants is poorly understood. We found that H3K27me3 and H3K4me3 are extensively reprogrammed throughout the development of Arabidopsis male gametophyte. This reprogramming leads to widespread chromatin bivalency and selective removal of H3K27me3 marks from key developmental regulators in sperm.

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Fig. 1: Summary of the distinct chromatin signatures in plant sperm.

References

  1. Heard, E. & Martienssen, R. A. Transgenerational epigenetic inheritance: myths and mechanisms. Cell 157, 95–109 (2014). A review article that discusses transgenerational epigenetic inheritance in animals and plants.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Baulcombe, D. C. & Dean, C. Epigenetic regulation in plant responses to the environment. Cold Spring Harb. Perspect. Biol. 6, a019471 (2014). A review article that summarizes H3K27me3-mediated FLC silencing and its resetting.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Brind’Amour, J. et al. An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations. Nat. Commun. 6, 6033 (2015). This paper reports an efficient workflow of ultra-low-input native ChIP-seq.

    Article  PubMed  Google Scholar 

  4. Schmidl, C., Rendeiro, A. F., Sheffield, N. C. & Bock, C. ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors. Nat. Methods 12, 963–965 (2015). This paper reports Tn5 transposase-based ChIP-seq library generation.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Borg, M. et al. Targeted reprogramming of H3K27me3 resets epigenetic memory in plant paternal chromatin. Nat. Cell Biol. 22, 621–629 (2020). This paper reports that the sperm-specific H3.10 histone variant is immune to H3K27me3 modification.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Macrae, T. A., Fothergill-Robinson, J. & Ramalho-Santos, M. Regulation, functions and transmission of bivalent chromatin during mammalian development. Nat. Rev. Mol. Cell Biol. 24, 6–26 (2023). A comprehensive review of chromatin bivalency.

    Article  CAS  PubMed  Google Scholar 

Download references

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This is a summary of: Zhu, D. et al. Distinct chromatin signatures in the Arabidopsis male gametophyte. Nat. Genet. https://doi.org/10.1038/s41588-023-01329-7 (2023).

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Prevalent putative chromatin bivalency and partial resetting of H3K27me3 in plant sperm. Nat Genet 55, 536–537 (2023). https://doi.org/10.1038/s41588-023-01345-7

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