Interacting proteins commonly perform similar functions. A protein interaction network analysis of genes linked to 1,002 human traits identifies molecular mechanisms that are shared across traits and so-called pleiotropic biological processes, whose disruption might affect many aspects of human biology.
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This is a summary of: Barrio-Hernandez, I. et al. Network expansion of genetic associations defines a pleiotropy map of human cell biology. Nat. Genet. https://doi.org/10.1038/s41588-023-01327-9 (2023).
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A pleiotropy map of cell biology covering 1,002 human traits. Nat Genet 55, 365–366 (2023). https://doi.org/10.1038/s41588-023-01328-8
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DOI: https://doi.org/10.1038/s41588-023-01328-8
