Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Briefing
  • Published:

A pleiotropy map of cell biology covering 1,002 human traits

Nature Genetics volume 55, pages 365–366 (2023)Cite this article

Subjects

Interacting proteins commonly perform similar functions. A protein interaction network analysis of genes linked to 1,002 human traits identifies molecular mechanisms that are shared across traits and so-called pleiotropic biological processes, whose disruption might affect many aspects of human biology.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Interacting proteins linked with bone-related traits and diseases.

References

  1. Mills, M. C. & Rahal, C. A scientometric review of genome-wide association studies. Commun. Biol. 2, 9 (2019). A review article that presents relevant discoveries and evolution of GWAS since 2005.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Ghoussaini, M. & Mountjoy, E. Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. Nucleic Acids Res. 49, 1311–1320 (2021). This paper describes the Open Target Genetics Portal.

    Article  Google Scholar 

  3. Choobdar, S. et al. Assessment of network module identification across complex diseases. Nat. Methods 16, 843–852 (2019). This paper benchmarks different methods for disease modules identification.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Federico, A. & Monti, S. Contextualized protein-protein interactions. Patterns (NY) 2, 1 (2020). This paper annotates interactions from the PPI database HIPPIE (http://cbdm.uni-mainz.de/hippie/) with biological context information (cell lines).

    Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Barrio-Hernandez, I. et al. Network expansion of genetic associations defines a pleiotropy map of human cell biology. Nat. Genet. https://doi.org/10.1038/s41588-023-01327-9 (2023).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

A pleiotropy map of cell biology covering 1,002 human traits. Nat Genet 55, 365–366 (2023). https://doi.org/10.1038/s41588-023-01328-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-023-01328-8

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing