Quantifying whether different populations share similar effect sizes of common causal variants is vital to understand the genetic basis of disease and build better prediction models. A new study proposes a method leveraging admixture to estimate the correlation of causal genetic variants and finds they are largely similar across ancestry backgrounds.
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References
Popejoy, A. B. Nature 538, 161–164 (2016).
Martin, A. R. et al. Nat. Genet. 51, 584–591 (2019).
Carlson, C. S. et al. PLoS Biol. 11, e1001661 (2013).
Hou, K. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01338-6 (2023).
Atkinson, E. G. et al. Nat. Genet. 53, 195–204 (2021).
Brown, B. C., Ye, C. J., Price, A. L. & Zaitlen, N. Am. J. Hum. Genet. 99, 76–88 (2016).
Galinsky, K. J. et al. Genet. Epidemiol. 43, 180–188 (2019).
Shi, H. et al. Nat. Comm. 12, 1098 (2021).
Patel, R. A. et al. Am. J. Hum. Genet. 109, 1286–1297 (2022).
Marigorta, U. M. & Navarro, A. PLoS Genet. 9, e1003566 (2013).
Saitou, M., Dahl, A., Wang, Q. & Liu, X. Preprint at medRxiv https://doi.org/10.1101/2022.10.21.22281371 (2022).
Mathieson, I. & McVean, G. PLoS Genet. 10, e1004528 (2014).
Mägi, R. et al. Hum. Mol. Genet. 26, 3639–3650 (2017).
Mills, M. C. & Rahal, C. Nat. Genet. 52, 242–243 (2020).
Sirugo, G., Williams, S. M. & Tishkoff, S. A. Cell 177, 26–31 (2019).
Acknowledgements
E.G.A. is supported by K01MH121659 from NIH/NIMH, the Caroline Wiess Law Fund for Research in Molecular Medicine, and the ARCO Foundation Young Teacher-Investigator Fund at Baylor College of Medicine.
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Atkinson, E.G. Estimation of cross-ancestry genetic correlations within ancestry tracts of admixed samples. Nat Genet 55, 527–529 (2023). https://doi.org/10.1038/s41588-023-01325-x
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DOI: https://doi.org/10.1038/s41588-023-01325-x