We introduce molecular and cellular criteria — based on morphology, ploidy, CpG island methylation and immune infiltration — that improve the characterization of malignant pleural mesothelioma. These criteria reveal adaptation strategies that are adopted by tumor cells and offer new possibilities for classification and clinical management.
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References
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This is a summary of: Mangiante, L. et al. Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity. Nat. Genet. https://doi.org/10.1038/s41588-023-01321-1 (2023).
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Lifting the curtain on molecular differences between malignant pleural mesotheliomas. Nat Genet 55, 540–541 (2023). https://doi.org/10.1038/s41588-023-01322-0
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DOI: https://doi.org/10.1038/s41588-023-01322-0
