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Cancer evolution

A medley of resistance in ovarian cancers

Nature Genetics volume 55, pages 361–362 (2023)Cite this article

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Multi-omic profiling of lesions at autopsy reveals a plethora of resistance mechanisms present within individual patients with ovarian cancer. This highlights the extreme challenge faced in treating end-stage disease and underscores the need for new methods of early detection and intervention.

Autopsy studies in cancer provide an unprecedented view of mechanisms of treatment resistance1. Autopsy studies are logistically challenging, requiring rapid sample collection after death, collaboration across different medical and scientific disciplines, and support from patients and families. They facilitate the collection of nearly all tumors in a patient, overcoming the sampling limitations of biopsy and surgical studies. Studies of resistance mechanisms through autopsy have largely been limited to small numbers of patients; however, in this issue of Nature Genetics, Burdett et al.2 report on the multi-omic profiling of 391 lesions collected across 15 patients with homologous recombination (HR)-deficient ovarian cancers.

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Fig. 1: Multi-omic characterization of resistance mechanisms.

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  1. Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    Barbara Hernando & Geoff Macintyre

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  1. Barbara Hernando
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  2. Geoff Macintyre
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Correspondence to Geoff Macintyre.

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Hernando, B., Macintyre, G. A medley of resistance in ovarian cancers. Nat Genet 55, 361–362 (2023). https://doi.org/10.1038/s41588-023-01303-3

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  • DOI: https://doi.org/10.1038/s41588-023-01303-3

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