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Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops

Using a series of mouse mutants, we found that the Sox2 promoter does not require CTCF–cohesin loops to interact with distal enhancers. Surprisingly, mice with varying numbers of CTCF motifs in different positions showed that some distal enhancers can bypass boundaries that are created by CTCF–cohesin loops to ensure robust Sox2 expression.

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Fig. 1: Some enhancers bypass CTCF loops.


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This is a summary of: Chakraborty, S. et al. Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness. Nat. Genet. (2023).

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Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops. Nat Genet 55, 174–175 (2023).

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