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A scalable technology for measuring cell-type-specific activity of cis-regulatory sequences

A high-throughput reporter gene assay for use in living tissues has been developed. The assay allows investigators to quantify, in parallel, the activities of reporter genes in each of the cell types that constitute a tissue.

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Fig. 1: scMPRA in the mouse retina.


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This is a summary of: Zhao, S. et al. A single-cell massively parallel reporter assay detects cell-type-specific gene regulation Nat. Genet. (2022).

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A scalable technology for measuring cell-type-specific activity of cis-regulatory sequences. Nat Genet (2023).

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