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Identifying type 2 diabetes risk genes by β-cell CRISPR screening

A major challenge in human genetics is the prioritization of causal genes in common complex diseases. A genome-wide CRISPR screen for intracellular insulin content in a human β-cell line has now identified a new candidate gene for type 2 diabetes, demonstrating the utility of this screening approach in β-cells.

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Fig. 1: Approach to identify genes important for insulin content in β-cells.


  1. Grotz, A. et al. Curr. Diab. Rep. 17, 76 (2017).

    Article  Google Scholar 

  2. Barroso, I. & McCarthy, M. I. Cell 177, 146–161 (2019).

    Article  CAS  Google Scholar 

  3. Rottner, A. K. et al. Nat. Genet. (2022).

  4. Ravassard, P. et al. J. Clin. Invest. 121, 3589–3597 (2011).

    Article  CAS  Google Scholar 

  5. Udler, M. S. et al. PLoS Med. 15, e1002654 (2018).

    Article  Google Scholar 

  6. Fang, Z. et al. Cell Rep. 26, 3132–3144 (2019).

    Article  CAS  Google Scholar 

  7. Cai, E. P. et al. Nat. Metab. 2, 934–945 (2020).

    Article  CAS  Google Scholar 

  8. Bevacqua, R. et al. Nat. Commun. 12, 2397 (2021).

    Article  CAS  Google Scholar 

  9. Krentz, N. A. J. & Gloyn, A. L. Nat. Rev. Endocrinol. 16, 202–212 (2020).

    Article  CAS  Google Scholar 

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Correspondence to Bridget K. Wagner.

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Wagner, B.K. Identifying type 2 diabetes risk genes by β-cell CRISPR screening. Nat Genet 55, 4–5 (2023).

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