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Diabetes

Identifying type 2 diabetes risk genes by β-cell CRISPR screening

A major challenge in human genetics is the prioritization of causal genes in common complex diseases. A genome-wide CRISPR screen for intracellular insulin content in a human β-cell line has now identified a new candidate gene for type 2 diabetes, demonstrating the utility of this screening approach in β-cells.

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Fig. 1: Approach to identify genes important for insulin content in β-cells.

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Correspondence to Bridget K. Wagner.

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Wagner, B.K. Identifying type 2 diabetes risk genes by β-cell CRISPR screening. Nat Genet 55, 4–5 (2023). https://doi.org/10.1038/s41588-022-01269-8

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