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sortChIC enables detailed chromatin analysis of rare cell types

Current methods of chromatin analysis focus mainly on the most abundant cell types in a sample. We present a workflow that combines enrichment of rare cell types with high-resolution mapping of histone modifications, which enables us to study chromatin dynamics in rare stem and progenitor cell populations.

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Fig. 1: Integration of FACS information into chromatin analysis.


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This is a summary of: Zeller, P. et al. Single-cell sortChIC identifies hierarchical chromatin dynamics during hematopoiesis. Nat. Genet. (2022).

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sortChIC enables detailed chromatin analysis of rare cell types. Nat Genet 55, 170–171 (2023).

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