Current methods of chromatin analysis focus mainly on the most abundant cell types in a sample. We present a workflow that combines enrichment of rare cell types with high-resolution mapping of histone modifications, which enables us to study chromatin dynamics in rare stem and progenitor cell populations.
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References
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This is a summary of: Zeller, P. et al. Single-cell sortChIC identifies hierarchical chromatin dynamics during hematopoiesis. Nat. Genet. https://doi.org/10.1038/s41588-022-01260-3 (2022).
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sortChIC enables detailed chromatin analysis of rare cell types. Nat Genet (2023). https://doi.org/10.1038/s41588-022-01259-w
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DOI: https://doi.org/10.1038/s41588-022-01259-w
