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Dissecting endometriosis by single-cell transcriptomic and genomic analysis

Endometriosis affects around 10% of individuals born with a uterus, yet we know remarkably little about its underlying biology. Our single-cell transcriptional profiling of endometrial-type epithelial and stromal cells is shedding light on the cells and processes that contribute to endometriosis, which opens up new avenues for diagnostics and therapeutics.

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Fig. 1: Transcriptional profiling of epithelial components of lesions from patients with endometriosis.

References

  1. Fonseca, M. A. S. et al. Single cell transcriptomic analysis of endometriosis. Nat. Genet. https://doi.org/10.1038/10.1038/s41588-022-01254-1 (2022). A paper that reports single-cell transcriptomic analysis of ~50 tissues from 17 patients with endometriosis and four individuals who are unaffected.

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  2. Tan, Y. et al. Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues. Nat. Cell Biol. 24, 1306–1318 (2022). This paper reports single-cell transcriptomic analyses of endometriosis in patients taking exogenous hormones, with a focus on the perivascular niche, and immune signatures of the peritoneum in affected individuals.

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This is a summary of: Fonseca, M. A. S. et al. Single-cell transcriptomic analysis of endometriosis. Nat. Genet. https://doi.org/10.1038/s41588-022-01254-1 (2022).

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Dissecting endometriosis by single-cell transcriptomic and genomic analysis. Nat Genet (2023). https://doi.org/10.1038/s41588-022-01255-0

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  • DOI: https://doi.org/10.1038/s41588-022-01255-0

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