This is a preview of subscription content, access via your institution
Subscribe to Nature+
Get immediate online access to Nature and 55 other Nature journal
Subscribe to Journal
Get full journal access for 1 year
only $6.58 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
The data used pertain to the GTEx project v.8. Gene expression data are freely available at https://gtexportal.org/home/. GTEx genotype data are available on application through the database of Genotypes and Phenotypes. This research was conducted using the UK Biobank resource under project no. 788. The GTEx regulatory and consent protocols can be found at https://biospecimens.cancer.gov/resources/sops/library.asp.
Bernabeu, E. et al. Sex differences in genetic architecture in the UK Biobank. Nat. Genet. 53, 1283–1289 (2021).
Li, Z. et al. Genotype by sex interactions in ankylosing spondylitis. Nat. Genet. https://doi.org/10.1038/s41588-022-01250-5 (2023).
Zhou, X. & Reveille, J. D. Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis. Ann. Rheum. Dis. 79, e1 (2020).
Cortes, A. et al. Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis. Ann. Rheum. Dis. 77, 1691–1692 (2018).
Zhou, W. et al. Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nat. Genet. 50, 1335–1341 (2018).
Mbatchou, J. et al. Computationally efficient whole-genome regression for quantitative and binary traits. Nat. Genet. 53, 1097–1103 (2021).
Jiang, L., Zheng, Z., Fang, H. & Yang, J. A generalized linear mixed model association tool for biobank-scale data. Nat. Genet. 53, 1616–1621 (2021).
Loh, P.-R., Kichaev, G., Gazal, S., Schoech, A. P. & Price, A. L. Mixed-model association for biobank-scale datasets. Nat. Genet. 50, 906–908 (2018).
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015).
Porcu, E. et al. Limited evidence for blood eQTLs in human sexual dimorphism. Genome Med. 14, 89 (2022).
Oliva, M. et al. The impact of sex on gene expression across human tissues. Science 369, eaba3066 (2020).
The authors declare no competing interests.
Peer review information
Nature Genetics thanks Seunggeun Lee and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Bernabeu, E., Rawlik, K., Canela-Xandri, O. et al. Reply to: Genotype by sex interactions in ankylosing spondylitis. Nat Genet 55, 17–18 (2023). https://doi.org/10.1038/s41588-022-01251-4
This article is cited by
Nature Genetics (2023)