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DNA methylation provides molecular links underlying complex traits

We profiled human DNA methylation for 987 GTEx samples across nine tissues and characterized how genetic regulation of the methylome, compared with the transcriptome, contributes to GWAS phenotypes. This resource contributes to our understanding of molecular regulatory mechanisms in human tissues and their effects on complex traits.

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Fig. 1: Multi-tissue DNAm analyses and QTL–GWAS colocalizations.

References

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This is a summary of: Oliva, M. et al. DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits. Nat. Genet. https://doi.org/10.1038/s41588-022-01248-z (2022).

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DNA methylation provides molecular links underlying complex traits. Nat Genet 55, 12–13 (2023). https://doi.org/10.1038/s41588-022-01249-y

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