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Diet modulates genetic effects on longevity

It is well known that dietary composition affects lifespan, but whether the effects of diet are mediated through interactions with genetics is unknown. By careful tracking of genome-wide allele frequency in Drosophila, we identify hundreds of loci that affect longevity only in the context of a high-sugar diet.

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Fig. 1: Experimental design to detect GxE interactions determining lifespan.


  1. Kirkwood, T. B. Understanding the odd science of aging. Cell 120, 437–447 (2005). This article reviews some of the leading hypotheses invoked to explain the evolution of senescence.

    Article  CAS  Google Scholar 

  2. Corbett, S., Courtiol, A., Lummaa, V., Moorad, J. & Stearns, S. The transition to modernity and chronic disease: mismatch and natural selection. Nat. Rev. Genet. 19, 419–430 (2018). A review article that explains the evolutionary mismatch hypothesis and how it may explain the emergence of modern human diseases.

    Article  CAS  Google Scholar 

  3. Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747–753 (2008). A review article that defines the missing heritability problem.

    Article  Google Scholar 

  4. Mostafavi, H., Berisa, T., Day, F. R., Perry, J. R., Przeworski, M. & Pickrell, J. K. Identifying genetic variants that affect viability in large cohorts. PLoS Biol. 15, e2002458 (2017). This article inspired our study and uses the UK Biobank to study viability selection in human populations.

    Article  Google Scholar 

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This is a summary of: Pallares, L. F. et al. Dietary stress remodels the genetic architecture of lifespan in outbred Drosophila. Nat. Genet. (2022).

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Diet modulates genetic effects on longevity. Nat Genet 55, 8–9 (2023).

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