It is well known that dietary composition affects lifespan, but whether the effects of diet are mediated through interactions with genetics is unknown. By careful tracking of genome-wide allele frequency in Drosophila, we identify hundreds of loci that affect longevity only in the context of a high-sugar diet.
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This is a summary of: Pallares, L. F. et al. Dietary stress remodels the genetic architecture of lifespan in outbred Drosophila. Nat. Genet. https://doi.org/10.1038/s41588-022-01246-1 (2022).
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Diet modulates genetic effects on longevity. Nat Genet 55, 8–9 (2023). https://doi.org/10.1038/s41588-022-01247-0
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DOI: https://doi.org/10.1038/s41588-022-01247-0
