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Diet modulates genetic effects on longevity

It is well known that dietary composition affects lifespan, but whether the effects of diet are mediated through interactions with genetics is unknown. By careful tracking of genome-wide allele frequency in Drosophila, we identify hundreds of loci that affect longevity only in the context of a high-sugar diet.

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Fig. 1: Experimental design to detect GxE interactions determining lifespan.

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This is a summary of: Pallares, L. F. et al. Dietary stress remodels the genetic architecture of lifespan in outbred Drosophila. Nat. Genet. https://doi.org/10.1038/s41588-022-01246-1 (2022).

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Diet modulates genetic effects on longevity. Nat Genet 55, 8–9 (2023). https://doi.org/10.1038/s41588-022-01247-0

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