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Spatial atlas reveals insight into lung immunity

The cell types of the lung enable gas exchange and protect against infection. Our spatial atlas of the human lung and airways revealed 11 new cell types and mapped their anatomical locations. In particular, we defined the gland-associated immune niche (GAIN), which is involved in fighting respiratory infections.

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Fig. 1: Spatial profiling of the lungs and airways.

References

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This is a summary of: Madissoon, E. et al. A spatially resolved atlas of the human lung characterizes a gland-associated immune niche. Nat. Genet. https://doi.org/10.1038/s41588-022-01243-4 (2022).

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Spatial atlas reveals insight into lung immunity. Nat Genet 55, 10–11 (2023). https://doi.org/10.1038/s41588-022-01244-3

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