Mutations in the sodium channel NALCN promote epithelial cell shedding and dissemination independent of oncogenic transformation. This observation suggests that metastasis may not uniformly represent the end stage of carcinogenesis but can occur before oncogenic transformation.
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References
Massague, J. & Obenauf, A. C. Nature 529, 298–306 (2016).
Rahrmann, E. P. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01182-0 (2022).
Podsypanina, K. et al. Science 321, 1841–1844 (2008).
Casasent, A. K. et al. Cell 172, 205–217 (2018).
Hosseini, H. et al. Nature 540, 552–558 (2016).
Sanger, N. et al. Int. J. Cancer 129, 2522–2526 (2011).
Schardt, J. A. et al. Cancer Cell 8, 227–239 (2005).
Ullah, I. et al. J. Clin. Invest. 128, 1355–1370 (2018).
Muzumdar, M. D. et al. Nat. Commun. 7, 12685 (2016).
Rhim, A. D. et al. Cell 148, 349–361 (2012).
Harper, K. L. et al. Nature 540, 588–592 (2016).
Makohon-Moore, A. P. et al. Nature 561, 201–205 (2018).
Shain, A. H. et al. Nat. Genet. 51, 1123–1130 (2019).
Hu, Z. et al. Nat. Genet. 51, 1113–1122 (2019).
Acharyya, S. et al. Cell 150, 165–178 (2012).
Acknowledgements
A.B. has received research funding from The Pew Charitable Trusts, Pershing Square Sohn Cancer Research Alliances, Joe W. and Dorothy Dorsett Brown Foundation, W.M. Keck Foundation, American Brain Tumor Association, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center, American Association for Cancer Research, National Institutes of Health, STARR Cancer Consortium, MSKCC Center for Experimental Therapeutics and FM Kirby Foundation.
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A.B. holds an unpaid position on the scientific advisory board of Evren Scientific, and is an inventor on the following patents: 62/258,044, 10413522 and 63/052,139. A.R.N. declares no competing interests.
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Nobre, A.R., Boire, A. Skip to the end: metastasis before tumorigenesis. Nat Genet 54, 1774–1775 (2022). https://doi.org/10.1038/s41588-022-01228-3
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DOI: https://doi.org/10.1038/s41588-022-01228-3
