Genetic risk factors for autism include both rare and common variants. A study shows that rare copy number variants and common variants across 16p that contribute to autism risk functionally converge to downregulate the expression of a large group of neuronally expressed genes in the 16p subtelomeric region.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Weiner, D. J. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01203-y (2022).
Won, H. et al. Nature 538, 523–527 (2016).
Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).
Loviglio, M. N. et al. Mol. Psychiatry 22, 836–849 (2017).
Fu, J. M. et al. Nat. Genet. 54, 1320–1331 (2022).
Babbs, C. et al. J. Med. Genet. 57, 414–421 (2020).
Raznahan, A., Won, H., Glahn, D. C. & Jacquemont, S. JAMA Psychiatry 79, 818–828 (2022).
Grove, J. et al. Nat. Genet. 51, 431–444 (2019).
Trubetskoy, V. et al. Nature 604, 502–508 (2022).
Hu, B. et al. Nat. Commun. 12, 3968 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Won, H., Huguet, G. & Jacquemont, S. Rare and common autism risk variants converge across 16p. Nat Genet 54, 1587–1588 (2022). https://doi.org/10.1038/s41588-022-01219-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-022-01219-4
