KCNK3 mutations identified in sleep apnea probands affect TASK-1 X-gate function. These changes lead to an increase in potassium current and open probability, as well as impaired sensitivity to G-protein-coupled receptor inhibitors.
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A.M. reports income related to medical education from Zoll, Livanova, Eli Lilly and Jazz. ResMed provided a philanthropic donation to University of California, San Diego. T.S.S. and E.A.M. declare no competing interests.
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Simonson, T.S., Moya, E.A. & Malhotra, A. Genomic insights into TASK-1 reveal functional roles in sleep apnea. Nat Genet 54, 1451–1452 (2022). https://doi.org/10.1038/s41588-022-01195-9
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DOI: https://doi.org/10.1038/s41588-022-01195-9